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USC feisty in return to practice field
DerekJohnson
Administrator, Swaye's Wigwam Posts: 60,097
DerekJohnson
Administrator, Swaye's Wigwam Posts: 60,097
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WE ARE SC! FIGHT ON!!!!!
NeedsMoreTime @NegaDawg 9m
“@CoachSark: WE ARE SC! FIGHT ON!!!!!” STFU you seven win bitch
You. Just. Can't.
It looks fun every now and then, but when the rubber hit the road we just couldn't get it done. That's not being a hater, that's a fact.
"We get to go look at this film as a staff. We get to visit with the players tomorrow, address the issues from the film and then come back Thursday and try to fix the issues that we have and build upon the things that we're doing well."
In other words, Sark and his lazy ass crew will decide that they need a bite to eat before getting into the film and head over to Socal equivalent of Joey's for "a bit" which will turn into a ton of beers and some hittin' on the staff and then tomorrow is kind of today and the "analysis" really doesn't happen so he ad libs feedback... ladies and gentlemen, it took a total of 4 practices for Sark to fall back to who he really is.
Sark's practice: Players getting chippy and a bunch of quotes about how they "are getting better" and "need to get faster."
The last time I felt this good in March I was on spring break, elbow-deep in co-eds and 25i-NBOMe. Those were the days. And now, just two weeks later, we are hearing about sloppy steve running a sloppy practice. Enjoy your seven wins, SC!
From Wikipedia, the free encyclopedia
25I-NBOMe
2C-I-NBOMe-skeletal.svg
25I-NBOMe-spacefill.png
Systematic (IUPAC) name
2-(4-iodo-2,5-dimethoxyphenyl)-N-[(2-methoxyphenyl)methyl]ethanamine
Clinical data
Legal status Temporary class drug (UK) Schedule I (Temporary Listing) (US)
Routes Buccal (sublabial), sublingual, insufflated, inhalation, intravenous, intramuscular, rectal
Identifiers
CAS number 919797-19-6
1043868-97-8 (hydrochloride)
ATC code None
PubChem CID 10251906
ChemSpider 8427392 Yes
Chemical data
Formula C18H22INO3
Mol. mass 427.28 g/mol
SMILES[show]
InChI[show]
(what is this?) (verify)
25I-NBOMe (2C-I-NBOMe, Cimbi-5) is a psychedelic drug and derivative of the substituted phenethylamine psychedelic 2C-I. It was discovered in 2003 by chemist Ralf Heim at the Free University of Berlin, who published his findings in his PhD dissertation.[1] The compound was subsequently investigated by a team at Purdue University led by David Nichols.[2]
The carbon-11 labelled version of 25I-NBOMe, [11C]Cimbi-5, was synthesized and validated as a radiotracer for positron emission tomography (PET) in Copenhagen.[3][4] Being the first 5-HT2A receptor full agonist PET radioligand, [11C]Cimbi-5 shows promise as a more functional marker of these receptors.[citation needed]
Contents [hide]
1 Chemistry and structure
1.1 Synthesis
2 Pharmacology
3 Recreational use
4 Dosage
5 Effects
5.1 Desired
5.2 Neutral
5.3 Undesired
5.4 Tolerance
6 Toxicity and harm potential
7 Legal status
7.1 Australia
7.2 Israel
7.3 Russia
7.4 Sweden
7.5 United Kingdom
7.6 United States
7.7 Romania
8 See also
9 References
10 External links
Chemistry and structure[edit]
Like other 2C-X-NBOMe molecules, 25I-NBOMe is a derivative of the 2C family of phenethylamines described by Alexander Shulgin in his book PiHKAL.[5][6] Specifically, 25I-NBOMe is an N-benzyl derivative of the phenethylamine molecule 2C-I, formed by adding a 2-methoxybenzyl (MeOB) onto the nitrogen (N) of the phenethylamine backbone. This substitution significantly increases the potency of the molecule.[5]
Synthesis[edit]
25I-NBOMe is usually synthesised from 2C-I and 2-methoxybenzaldehyde, in a reductive alkylation. It can be done stepwise by first making the imine and then reducing the formed imine with sodium borohydride, or by direct reaction with sodium triacetoxyborohydride.[1]
Pharmacology[edit]
Ki-values[7][8]
Receptor Ki (nM) ±
5-HT2A 0.044
5-HT2C 2
5-HT6 73 12
μ-opioid 82 14
H1 189 35
5-HT2B 231 73
κ-opioid 288 50
25I-NBOMe acts as a highly potent full agonist for the human 5-HT2A receptor,[7][9] with a Ki of 0.044 nM, making it some sixteen times the potency of 2C-I itself, and a radiolabelled form of 25I-NBOMe can be used for mapping the distribution of 5-HT2A receptors in the brain.[8] It is one of the only full agonists of the human 5-HT2A in existence. In vitro tests showed this compound acted as an agonist. Head twitch studies in mice have confirmed that 25I-NBOMe activates the 5-HT2A receptor in vivo, and demonstrated that 25I-NBOMe is approximately 14-fold more potent than 2C-I.[10] While the in vitro studies showed that N-benzyl derivatives of 2C-I were significantly increased in potency compared to 2C-I, the N-benzyl derivatives of DOI were inactive.[11]
Ki values of the following targets were greater than 500 nM: 5-HT1A, D3, H2, 5-HT1D, α1A adrenergic, δ opioid, serotonin uptake transporter, 5-HT5A, 5-HT1B, D2, 5-HT7, D1, 5-HT3, 5-HT1E, D5, muscarinic M1-M5, H3, and the dopamine uptake transporter.[8]
A forensic standard of 25I-NBOMe is available, and the compound has been posted on the Forendex website of potential drugs of abuse.[12]
25I-NBOMe induces a head-twitch response in mice which is blocked completely by a selective 5-HT2A antagonist, suggesting its psychedelic effects are mediated by 5-HT2A.[13]
Recreational use[edit]
Although 25I-NBOMe was discovered in 2003, it did not emerge as a common recreational drug until 2010, when it was first sold by vendors specialising in the supply of research chemicals.[citation needed] In a slang context, the name of the compound is often shortened to “25I”. According to a 2014 survery, 25I-NBOMe is the most frequently used of the NBOMe series.[14] Case reports of 25I-NBOMe intoxication, with and without analytic confirmation of the drug in the body, are increasing in the medical literature.[6]
25I-NBOMe is inactive orally, and the most common methods of administration are sublingual, buccal, and nasal.[14] For sublingual and buccal administration, 25I-NBOMe is applied to sheets of blotter paper — usually perforated with a uniform grid — of which small portions (tabs) are placed under the tongue or in the buccal space of the mouth, where the drug can be readily absorbed via mucous membranes.[5] There are reports of intravenous injection of 25I-NBOMe solution and smoking the drug in powdered form.[15][16]
Due to its potency, small quantities of 25I-NBOMe can provide a large numbers of doses. Vendors may import 25I-NBOMe in bulk and resell individual doses for considerable profit.[5]
Because blotter paper is also a common distribution medium for LSD, 25I-NBOMe blotters are sometimes misrepresented as, and mistaken for, LSD blotters.[17] It is challenging to differentiate the two using sensory techniques but reagent testing (particularly ehrlich's reagent) can be used to easily differentiate ergolines from 25-I NBOMe by a colour change.[18]
Dosage[edit]
25I-NBOMe is potent, being active in sub-milligram doses. A common dose of the hydrochloride salt is 600–1,200 µg. The UK Advisory Council on the Misuse of Drugs states that a common dose is between 50 and 100 µg,[5] although other sources indicate that these figures are incorrect; Erowid tentatively suggests that the threshold dosage for humans is 50–250 µg, with a light dose between 200–600 µg, a common dose at 500–800 µg, and a strong dose at 700–1500 µg.[19] At this level of potency, it is not possible to accurately measure a single dose of the powder without an analytically balance, and attempting to do so may put the user at risk of overdose.[5]
Effects[edit]
25I-NBOMe effects usually last 6–10 hours if taken sublingually or buccally.[16] When it is insufflated, effects usually last 4–6 hours.[16] Effects can however last significantly longer depending on dosage; durations longer than 12 hours have been reported.
25I-NBOMe can also be vaporized and inhaled, this may cause significantly quicker effects and shorter duration as is expected from that route of administration. This route of administration is however not recommended, unless when using precise liquid measurement, due to the difficulties of measuring and handling substances active in the microgram range.
25I-NBOMe has similar effects to LSD, though users report more negative effects while high and more risk of harm following use as compared to other classic psychedelics.[14]
Case reports of seven British males who presented to an emergency room following analytically confirmed 25I-NBOMe intoxication suggest the following potential adverse effects: tachycardia (n = 7), hypertension (4), agitation (6), aggression, visual and auditory hallucinations (6), seizures (3), hyperpyrexia (3), clonus (2), elevated white cell count (2), elevated creatine kinase (7), metabolic acidosis (3), and acute kidney injury (1).[15]
Desired[edit]
strong open- and closed-eye visuals, including trails, color shifts, brightening, etc.[16]
mood lift
euphoria
mental and physical stimulation
increase in associative & creative thinking
increased awareness & appreciation of music
life-changing spiritual experiences
feelings of love and empathy
increased pattern recognition
synesthesia and chromesthesia (intensified for those who typically experience these)
Neutral[edit]
general change in consciousness
pupil dilation
unusual body sensations (paresthesia, flushing, chills, goose bumps)
change in perception of time, time dilation
increased heart rate
jaw clenching (bruxism)
yawning, especially when coming up
insomnia
looping, recursive, out-of-control thinking
Undesired[edit]
(Includes negative side effects arising from overdose; likelihood of negative side effects increases with dose)
confusion and difficulty focusing
scrambled communication
vasoconstriction
nausea and vomiting (normally only during the onset for those affected)
paranoia, fear, and panic
unwanted and overwhelming feelings or life-changing spiritual experiences
syncopy
shaking
dystonia, clonus and seizure
death (Usually only reported in extremely high doses)
Tolerance[edit]
Users of 25I-NBOMe have reported that it causes physiological tolerance that may last for around 2-4 weeks. This tolerance is described as diminishing the efficacy of subsequent doses of 25I-NBOMe, as well as interfering with the efficacy of other phenethylamines.[20] This kind of temporary, rapidly-developed tolerance is a typical side effect of a number of other drugs of the phenethylamine class, such as MDMA.This tolerance will also affect the tolerance one has to a variety of other drugs.
Toxicity and harm potential[edit]
Recreational use of 25I-NBOME carries significant risk of both pharmacological and behavioral toxicity.[6][15] 25I-NBOMe is a relatively new substance, and little is known about its pharmacological risks or its interaction with other substances. The LD50 has not yet been determined.[21] It is a highly potent serotonin agonist and, due to its psychedelic effects and ambiguous legal status, a designer drug with reports of recreational use beginning in 2010. Reports of deaths and significant injuries have been attributed to the use of 25I-NBOMe, prompting some governments to control its possession, production, and sale. The harm-reduction website Erowid states that 25I-NBOMe is extremely potent and should not be snorted as this method of administration “appears to have led to several deaths in the past year.”[17] Several non-fatal overdoses requiring prolonged hospitalization have also been reported.[5][6][15]
The BBC carried a report in 2014 of a 26-year-old male who took "N-bomb" and drank alcohol the previous year at a party in Cornwall, and was found by passers-by having a seizure.
As of May 2013, 25I-NBOMe has reportedly led to five overdose deaths in the United States.[22] In June 2012, two teens in Grand Forks, North Dakota and East Grand Forks, Minnesota fatally overdosed on a substance that was allegedly 25I-NBOMe, resulting in lengthy sentences for two of the parties involved and a Federal indictment against the Texas based online vendor.[23] A 21-year-old man from Little Rock, Arkansas died in October 2012 after taking a liquid drop of the drug nasally at a music festival. He was reported to have consumed caffeinated alcoholic beverages for “several hours” beforehand. It is unclear what other drugs he may have consumed, as autopsies generally do not test for the presence of research chemicals.[24][25] In January 2013, an 18 year-old in Scottsdale, Arizona, died after consuming 25I-NBOMe sold as LSD; a toxicology screening found no other drugs in the person's system. The drug is the suspected cause of death in another Scottsdale, Arizona, incident in April 2013.[5]
25I-NBOMe has been implicated in multiple deaths in Australia.[5] In March 2012, a man in Australia died from injuries sustained by running into trees and power poles while intoxicated by 25I-NBOMe.[26] A Sydney teenager jumped to his death on June 5, 2013. He reportedly jumped off a balcony thinking he could fly.[27]
Legal status[edit]
Australia[edit]
25I-NBOMe was explicitly scheduled in Queensland (Australian) drug law in April 2012, and in New South Wales in October 2013, as were some related compounds such as 25B-NBOMe. The Australian federal government has no specific legislation concerning any of the N-benzyl phenethylamines.[citation needed]
Israel[edit]
Israel banned 25I-NBOMe in 2013.[28]
Russia[edit]
Russia was the first country to pass specific regulations on the NBOME series. All drugs in the NBOMe series, including 25I-NBOMe, became illegal in Russia in October 2011.[28]
Sweden[edit]
25I-NBOMe was classified as a Schedule I substance in publication LVFS 2013:15 by the Medical Products Agency.[29] The classification took effect on 1 Aug, 2013.
United Kingdom[edit]
N-benzylated phenethylamines such as 25I-NBOMe were initially unaffected by the legal status of phenethylamine-class drugs.[5] The British government issued a temporary class drug order on a list of emerging recreational drugs, including 25I-NBOMe, on 4 June 2013. The order, which took effect on 10 June 2013 and will last for up to twelve months, prohibits the production, import and sale of “the NBOMe and Benzofury groups of substances”.[30]
The UK Home Office announced that 25I-NBOMe would be made a class A drug on 10th June 2014 alongside every other N-benzyl phenethylamine.[31]
United States[edit]
On Nov 15, 2013, the DEA added 25I-NBOMe (and 25C-, and 25B-NBOMe) to Schedule I using their emergency scheduling powers, making those NBOMe compounds "temporarily" in Schedule I for two years.[32]
Romania[edit]
In 2011, Romania banned all psychoactive substances,[33] no matter what they really are.[34]
See also[edit]
2CBCB-NBOMe (NBOMe-TCB-2)
2CBFly-NBOMe (NBOMe-2CB-Fly)
25C-NBOMe (NBOMe-2CC)
25B-NBOMe (NBOMe-2CB)
25I-NBMD (NBMD-2CI)
25I-NBOH (NBOH-2CI)
25I-NBF (NBF-2CI)
5-MeO-NBpBrT
That quote is still awesome. Sark is obsessed with the number 7(shocker) and quotes the Doog script.
Abundance.
I could see the logic if you know, you were a professional team, and arguably the best in the league, and didn't need any additional work other than a walk through of some fundamentals.
Last I checked, SC isn't that team. Fight on Dude Brah.