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Why is chloroquine so controversial?

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Comments

  • MikeDamone
    MikeDamone Member Posts: 37,781
    MelloDawg said:

    MelloDawg said:

    MelloDawg said:

    Seems it’s worth a very serious look.

    BUT TRUMP SAID IT!



    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1232869/



    Background

    Severe acute respiratory syndrome (SARS) is caused by a newly discovered coronavirus (SARS-CoV). No effective prophylactic or post-exposure therapy is currently available.

    Results

    We report, however, that chloroquine has strong antiviral effects on SARS-CoV infection of primate cells. These inhibitory effects are observed when the cells are treated with the drug either before or after exposure to the virus, suggesting both prophylactic and therapeutic advantage. In addition to the well-known functions of chloroquine such as elevations of endosomal pH, the drug appears to interfere with terminal glycosylation of the cellular receptor, angiotensin-converting enzyme 2. This may negatively influence the virus-receptor binding and abrogate the infection, with further ramifications by the elevation of vesicular pH, resulting in the inhibition of infection and spread of SARS CoV at clinically admissible concentrations.

    Conclusion

    Chloroquine is effective in preventing the spread of SARS CoV in cell culture. Favorable inhibition of virus spread was observed when the cells were either treated with chloroquine prior to or after SARS CoV infection. In addition, the indirect immunofluorescence assay described herein represents a simple and rapid method for screening SARS-CoV antiviral compounds.

    Could you elaborate? You seem to understand the science of what was said in this abstract.
    It simply means the narrative rejection of chloroquine is political hyperbole, not science.
    There is science which casts doubt on it as well and the narrative rejection you see in the mainstream news at times contains that science. Some say you can take it and improve. Some say it doesn’t have the impact Trump suggests. Neither are made up studies. This is how scientific method works. The fringe websites will always be political in nature.
    I’d say that www.ncbi.nlm.nih.gov isn’t a fringe website.
    You are correct, that was not political in nature. I imagine I could find a .gov website which has an opposite set of findings. Science is exciting!
    The point is the left and media are making it into an issue only because Trump mentioned it. That’s all.
  • doogie
    doogie Member Posts: 15,072
    so what you’re saying is, the Press is now causing needless death by interfering in Life saving Science and Research?
  • GrundleStiltzkin
    GrundleStiltzkin Member Posts: 61,516 Standard Supporter
    doogie said:

    so what you’re saying is, the Press is now causing needless death by interfering in Life saving Science and Research?

    Experts say, yes.
  • Kaepsknee
    Kaepsknee Member Posts: 14,913
    MelloDawg said:

    MelloDawg said:

    Seems it’s worth a very serious look.

    BUT TRUMP SAID IT!



    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1232869/



    Background

    Severe acute respiratory syndrome (SARS) is caused by a newly discovered coronavirus (SARS-CoV). No effective prophylactic or post-exposure therapy is currently available.

    Results

    We report, however, that chloroquine has strong antiviral effects on SARS-CoV infection of primate cells. These inhibitory effects are observed when the cells are treated with the drug either before or after exposure to the virus, suggesting both prophylactic and therapeutic advantage. In addition to the well-known functions of chloroquine such as elevations of endosomal pH, the drug appears to interfere with terminal glycosylation of the cellular receptor, angiotensin-converting enzyme 2. This may negatively influence the virus-receptor binding and abrogate the infection, with further ramifications by the elevation of vesicular pH, resulting in the inhibition of infection and spread of SARS CoV at clinically admissible concentrations.

    Conclusion

    Chloroquine is effective in preventing the spread of SARS CoV in cell culture. Favorable inhibition of virus spread was observed when the cells were either treated with chloroquine prior to or after SARS CoV infection. In addition, the indirect immunofluorescence assay described herein represents a simple and rapid method for screening SARS-CoV antiviral compounds.

    Could you elaborate? You seem to understand the science of what was said in this abstract.
    It simply means the narrative rejection of chloroquine is political hyperbole, not science.
    There is science which casts doubt on it as well and the narrative rejection you see in the mainstream news at times contains that science. Some say you can take it and improve. Some say it doesn’t have the impact Trump suggests. Neither are made up studies. This is how scientific method works. The fringe websites will always be political in nature.
    When used as intended, meaning within the first few days of infection, it does a great job of stopping the infection mixed with the antibiotic. The biggest test of it here was in New York where it was set up to fail by using on patients that were already on a vent. It has no effectiveness then and the Rats in charge of this whole thing new this. Still haven't seen any documented success for Remdisvr.
  • GrundleStiltzkin
    GrundleStiltzkin Member Posts: 61,516 Standard Supporter
    salemcoog said:

    MelloDawg said:

    MelloDawg said:

    Seems it’s worth a very serious look.

    BUT TRUMP SAID IT!



    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1232869/



    Background

    Severe acute respiratory syndrome (SARS) is caused by a newly discovered coronavirus (SARS-CoV). No effective prophylactic or post-exposure therapy is currently available.

    Results

    We report, however, that chloroquine has strong antiviral effects on SARS-CoV infection of primate cells. These inhibitory effects are observed when the cells are treated with the drug either before or after exposure to the virus, suggesting both prophylactic and therapeutic advantage. In addition to the well-known functions of chloroquine such as elevations of endosomal pH, the drug appears to interfere with terminal glycosylation of the cellular receptor, angiotensin-converting enzyme 2. This may negatively influence the virus-receptor binding and abrogate the infection, with further ramifications by the elevation of vesicular pH, resulting in the inhibition of infection and spread of SARS CoV at clinically admissible concentrations.

    Conclusion

    Chloroquine is effective in preventing the spread of SARS CoV in cell culture. Favorable inhibition of virus spread was observed when the cells were either treated with chloroquine prior to or after SARS CoV infection. In addition, the indirect immunofluorescence assay described herein represents a simple and rapid method for screening SARS-CoV antiviral compounds.

    Could you elaborate? You seem to understand the science of what was said in this abstract.
    It simply means the narrative rejection of chloroquine is political hyperbole, not science.
    There is science which casts doubt on it as well and the narrative rejection you see in the mainstream news at times contains that science. Some say you can take it and improve. Some say it doesn’t have the impact Trump suggests. Neither are made up studies. This is how scientific method works. The fringe websites will always be political in nature.
    When used as intended, meaning within the first few days of infection, it does a great job of stopping the infection mixed with the antibiotic and zinc. The biggest test of it here was in New York where it was set up to fail by using on patients that were already on a vent. It has no effectiveness then and the Rats in charge of this whole thing new this. Still haven't seen any documented success for Remdisvr.
    Or so some Experts Say.
  • LoneStarDawg
    LoneStarDawg Member, Swaye's Wigwam Posts: 13,681 Founders Club
    Why is a Zpack used? Just trying to fight off secondary infection?
  • GrundleStiltzkin
    GrundleStiltzkin Member Posts: 61,516 Standard Supporter

    Why is a Zpack used? Just trying to fight off secondary infection?

    Yes.
  • Bob_C
    Bob_C Member, Swaye's Wigwam Posts: 12,728 Founders Club



    I honestly don't get what the big deal is. It's 'script only, so people can't run out & get it. It might work, and maybe more likely doesn't work. TDS is skrong.
    The amount of deceptive and inaccurate reporting on this drug has been off-the-charts. Media personalities were mocking it as "completely ineffective" i.e., only idiots would believe it worked at all, while some people were actually and demonstrably benefitting from it.

    I read very few articles that said it flat out didn't work, but instead read many, many articles and studies that said it was potentially dangerous to anyone with heart problems or taking meds for blood pressure, arrhythmia, irregular heartbeat, etc., so it wasn't "recommended." That's not the same thing as banning it or suggesting it was malpractice to prescribe it, but that didn't matter at all to the mainstream media. It was all about crushing any optimism coming from the White House or anyone who saw a potential path through the crisis.

    The Media wants this crisis to last until the election so the Left can beat Trump. It couldn't be more obvious, and at this point, you pretty much know the media personalities are lying if their lips are moving. Yes, it really has gotten that bad.
    The irony is that Trump is good for media content and for business. What are they going to talk about if he’s gone?
  • Sledog
    Sledog Member Posts: 37,861 Standard Supporter
    Quinine is so controversial because because if there's a cure there is no need for a lockdown and the dems push to destroy the economy in order to destroy Trump.
  • doogie
    doogie Member Posts: 15,072
    Isn’t treatment always a private discussion between Patient and Doctor?
  • NorthwestFresh
    NorthwestFresh Member Posts: 7,972
    edited May 2020
    Bob_C said:



    I honestly don't get what the big deal is. It's 'script only, so people can't run out & get it. It might work, and maybe more likely doesn't work. TDS is skrong.
    The amount of deceptive and inaccurate reporting on this drug has been off-the-charts. Media personalities were mocking it as "completely ineffective" i.e., only idiots would believe it worked at all, while some people were actually and demonstrably benefitting from it.

    I read very few articles that said it flat out didn't work, but instead read many, many articles and studies that said it was potentially dangerous to anyone with heart problems or taking meds for blood pressure, arrhythmia, irregular heartbeat, etc., so it wasn't "recommended." That's not the same thing as banning it or suggesting it was malpractice to prescribe it, but that didn't matter at all to the mainstream media. It was all about crushing any optimism coming from the White House or anyone who saw a potential path through the crisis.

    The Media wants this crisis to last until the election so the Left can beat Trump. It couldn't be more obvious, and at this point, you pretty much know the media personalities are lying if their lips are moving. Yes, it really has gotten that bad.
    The irony is that Trump is good for media content and for business. What are they going to talk about if he’s gone?
    The Biden DOJ investigating and prosecuting all things Trump as an example to any political outsiders/upstarts who dare try and derail the DC Gravy Train. I already have their narrative written for them. Intellectual property, bitches!
  • GrundleStiltzkin
    GrundleStiltzkin Member Posts: 61,516 Standard Supporter
    doogie said:

    Isn’t treatment always a private discussion between Patient and Doctor?

    HIPPA has been canceled.
  • PurpleThrobber
    PurpleThrobber Member Posts: 48,124 Standard Supporter



    I honestly don't get what the big deal is. It's 'script only, so people can't run out & get it. It might work, and maybe more likely doesn't work. TDS is skrong.
    The amount of deceptive and inaccurate reporting on this drug has been off-the-charts. Media personalities were mocking it as "completely ineffective" i.e., only idiots would believe it worked at all, while some people were actually and demonstrably benefitting from it.

    I read very few articles that said it flat out didn't work, but instead read many, many articles and studies that said it was potentially dangerous to anyone with heart problems or taking meds for blood pressure, arrhythmia, irregular heartbeat, etc., so it wasn't "recommended." That's not the same thing as banning it or suggesting it was malpractice to prescribe it, but that didn't matter at all to the mainstream media. It was all about crushing any optimism coming from the White House or anyone who saw a potential path through the crisis.

    The Media wants this crisis to last until the election so the Left can beat Trump. It couldn't be more obvious, and at this point, you pretty much know the media personalities are lying if their lips are moving. Yes, it really has gotten that bad.
    I've said many times before - the public is dumb but they aren't stupid. They know they are getting played by the governors and by the media trying to AAAARRGH MEAN ORANGE MAN all this.

    This is pretty well the most fucked up thing the left could do - all they had to do was walk up to the election and put ANYBODY up against Trump and had a chance. Instead, they are playing games and offering up Biden.

    Trump, rather easily, 34-17.

  • PostGameOrangeSlices
    PostGameOrangeSlices Member Posts: 27,217
    edited May 2020
    It's controversial because Orange Man Bad
  • NorthwestFresh
    NorthwestFresh Member Posts: 7,972

    doogie said:

    Isn’t treatment always a private discussion between Patient and Doctor?

    HIPPA has been canceled.
    Kind of a dumb pet peeve but it’s HIPAA, not HIPPA. I was in healthcare for a few decades working with the cream of the jizz after that law was enacted.
  • GrundleStiltzkin
    GrundleStiltzkin Member Posts: 61,516 Standard Supporter

    doogie said:

    Isn’t treatment always a private discussion between Patient and Doctor?

    HIPPA has been canceled.
    Kind of a dumb pet peeve but it’s HIPAA, not HIPPA. I was in healthcare for a few decades working with the cream of the jizz after that law was enacted.
    Quite honestly, I don't give a shit.
  • TurdBomber
    TurdBomber Member Posts: 20,041 Standard Supporter
    MelloDawg said:

    MelloDawg said:

    Seems it’s worth a very serious look.

    BUT TRUMP SAID IT!



    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1232869/



    Background

    Severe acute respiratory syndrome (SARS) is caused by a newly discovered coronavirus (SARS-CoV). No effective prophylactic or post-exposure therapy is currently available.

    Results

    We report, however, that chloroquine has strong antiviral effects on SARS-CoV infection of primate cells. These inhibitory effects are observed when the cells are treated with the drug either before or after exposure to the virus, suggesting both prophylactic and therapeutic advantage. In addition to the well-known functions of chloroquine such as elevations of endosomal pH, the drug appears to interfere with terminal glycosylation of the cellular receptor, angiotensin-converting enzyme 2. This may negatively influence the virus-receptor binding and abrogate the infection, with further ramifications by the elevation of vesicular pH, resulting in the inhibition of infection and spread of SARS CoV at clinically admissible concentrations.

    Conclusion

    Chloroquine is effective in preventing the spread of SARS CoV in cell culture. Favorable inhibition of virus spread was observed when the cells were either treated with chloroquine prior to or after SARS CoV infection. In addition, the indirect immunofluorescence assay described herein represents a simple and rapid method for screening SARS-CoV antiviral compounds.

    Could you elaborate? You seem to understand the science of what was said in this abstract.
    It simply means the narrative rejection of chloroquine is political hyperbole, not science.
    There is science which casts doubt on it as well and the narrative rejection you see in the mainstream news at times contains that science. Some say you can take it and improve. Some say it doesn’t have the impact Trump suggests. Neither are made up studies. This is how scientific method works. The fringe websites will always be political in nature.

    Did you play this character on Veep, by chance? You sound like her.
  • TurdBomber
    TurdBomber Member Posts: 20,041 Standard Supporter
    Bob_C said:



    I honestly don't get what the big deal is. It's 'script only, so people can't run out & get it. It might work, and maybe more likely doesn't work. TDS is skrong.
    The amount of deceptive and inaccurate reporting on this drug has been off-the-charts. Media personalities were mocking it as "completely ineffective" i.e., only idiots would believe it worked at all, while some people were actually and demonstrably benefitting from it.

    I read very few articles that said it flat out didn't work, but instead read many, many articles and studies that said it was potentially dangerous to anyone with heart problems or taking meds for blood pressure, arrhythmia, irregular heartbeat, etc., so it wasn't "recommended." That's not the same thing as banning it or suggesting it was malpractice to prescribe it, but that didn't matter at all to the mainstream media. It was all about crushing any optimism coming from the White House or anyone who saw a potential path through the crisis.

    The Media wants this crisis to last until the election so the Left can beat Trump. It couldn't be more obvious, and at this point, you pretty much know the media personalities are lying if their lips are moving. Yes, it really has gotten that bad.
    The irony is that Trump is good for media content and for business. What are they going to talk about if he’s gone?
    They should just REPORT not opine and narrate with callous disregard for the truth, under the guise of "news." No matter which side you're on, or how far toward the edge you are, the American Press is doing far more harm to you than good. Dems and the Left need to realize this; The Right already does. It's already too late for 2020, but it's needed for 2022 and beyond.
  • MikeDamone
    MikeDamone Member Posts: 37,781

    Why is a Zpack used? Just trying to fight off secondary infection?

    Chlamydia
  • doogie
    doogie Member Posts: 15,072
    Whoa

    Org psychologist. Author. Coach. Speaker
  • TurdBomber
    TurdBomber Member Posts: 20,041 Standard Supporter
    doogie said:

    Whoa

    Org psychologist. Author. Coach. Speaker
    And Twitter Hero
  • doogie
    doogie Member Posts: 15,072
    James Todaro doesn’t sound Indian to me. If this guy is legit, why don’t we see him on CNN or NBC?
  • Alexis
    Alexis Member, Swaye's Wigwam Posts: 3,395 Founders Club
    My mom has taken hydoxychloroquine for years for rheumatoid arthritis. I live in her basement. I haven't sheltered in place for shit, and scoff at mask wearing douches daily. She has not gotten the CRUD2020, though obviously I have brought it home numerous times. Ergo it obviously works.

    Fucking Science!